Safety and Quality of Life of Peri-Operative Transdermal Estradiol Continuation During Gender Affirmation Surgery in Transgender Women: A Randomised Placebo-Controlled Trial

Grant number: 2003939 | Funding period: 2021 - 2023

Completed

Abstract

Despite no clear evidence, transgender women are told to stop their feminising estrogen treatment several weeks before gender surgery, but this causes severe 'menopausal symptoms' with hot flushes, depression and distress compounding an already stressful preparation for and recovery from major surgery. This trial will establish if continuing estrogen gel around the time of surgery is safe and effective at improving 'menopausal symptoms'.

Related publications (16)

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In Australia, as overseas, the number of transgender and gender- diverse (trans) people seeking hormone therapy for gender affirma..

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Testosterone and Quality of Life in Transgender and Gender-Diverse Adults Seeking Masculinization: A Secondary Analysis of a Randomized Clinical Trial

BJ Nolan, S Zwickl, P Locke, AS Cheung

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Introduction: Testosterone treatment is a necessary component of gender affirmation for some transgender and gender-diverse adults..

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Response to Letter to the Editor From Kirk & Stebbings: The Impact of Gender-Affirming Hormone Therapy on Physical Performance

AS Cheung, S Zwickl, K Miller, BJ Nolan, AFQ Wong, P Jones, N Eynon

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The Impact of Gender-Affirming Hormone Therapy on Physical Performance

AS Cheung, S Zwickl, K Miller, BJ Nolan, AFQ Wong, P Jones, N Eynon

2024-02-01

Context: The inclusion of transgender people in elite sport has been a topic of debate. This narrative review examines the impact ..

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Early Access to Testosterone Therapy in Transgender and Gender-Diverse Adults Seeking Masculinization A Randomized Clinical Trial

Brendan J Nolan, Sav Zwickl, Peter Locke, Jeffrey D Zajac, Ada S Cheung

2023-09-07

Importance: Testosterone treatment is a necessary component of care for some transgender and gender-diverse individuals. Observati..

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Implications of gender-affirming endocrine care for sports participation

E Moreland, AS Cheung, D Hiam, BJ Nolan, S Landen, M Jacques, N Eynon, P Jones

2023-01-01

Many transgender (trans) individuals utilize gender-affirming hormone therapy (GAHT) to promote changes in secondary sex character..

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Transgender health and the impact of aging and menopause

AS Cheung, BJ Nolan, S Zwickl

2023-01-01

Gender affirming hormone therapy (GAHT) is used by many transgender people to reduce gender incongruence and improve psychological..

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Retrospective analysis of an intensive medical weight loss program in adults with obesity and severe or end-stage chronic kidney disease

J Cheng, BJ Nolan, P Sumithran

2022-11-01

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Single-center real-life experience with testosterone treatment in adult men with Prader–Willi syndrome

BJ Nolan, J Proietto, P Sumithran

2022-09-01

Hypogonadism is the most frequent hormonal deficiency in individuals with Prader-Willi syndrome (PWS). This often necessitates tes..

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Clinical features and prevalence of Klinefelter syndrome in transgender individuals: A systematic review

B Liang, AS Cheung, BJ Nolan

2022-07-01

Objective: Previous studies have suggested a higher prevalence of Klinefelter syndrome amongst transgender individuals. We underto..

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Intensive management of obesity in people with Prader-Willi syndrome

BJ Nolan, J Proietto, P Sumithran

2022-06-01

Purpose: Prader-Willi syndrome (PWS) is characterised by childhood-onset hyperphagia and obesity however limited data are availabl..

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Prescription Patterns and Testosterone Concentrations Achieved With AndroForte 5% Testosterone Cream in Transgender and Gender Diverse Individuals

BJ Nolan, S Zwickl, P Locke, S Simpson, L Li, JD Zajac, AS Cheung

2022-06-01

Background: Masculinizing hormone therapy with testosterone is used to align an individual's physical characteristics with their g..

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Uncovering the effects of gender affirming hormone therapy on skeletal muscle and epigenetics: protocol for a prospective matched cohort study in transgender individuals (the GAME study)

PR Jones, S Voisin, BJ Nolan, S Landen, M Jacques, B Newell, S Zwickl, T Cook, A Wong, A Ginger, A Palmer, A Garnham, J Alvarez-Romero, N Mohandas, K Seale, A Cheung, N Eynon

2022-05-11

Introduction Gender affirming hormone therapy (GAHT) is increasingly used by transgender individuals and leads to shifts in sex ho..

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Effects of low-dose oral micronised progesterone on sleep, psychological distress, and breast development in transgender individuals undergoing feminising hormone therapy: a prospective controlled study

BJ Nolan, AS Frydman, SY Leemaqz, M Carroll, M Grossmann, JD Zajac, AS Cheung

2022-05-01

Objective: The role of micronised progesterone in hormone regimens for transgender individuals undergoing feminising hormone thera..

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Testosterone concentrations and prescription patterns of 1% testosterone gel in transgender and gender diverse individuals

BJ Nolan, S Zwickl, AFQ Wong, P Locke, S Simpson, L Li, JD Zajac, AS Cheung

2022-03-01

Background: Masculinising hormone therapy with testosterone is used to align an individual’s physical characteristics with their g..

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Feminizing Hormone Therapy Prescription Patterns and Cardiovascular Risk Factors in Aging Transgender Individuals in Australia

MI Balcerek, BJ Nolan, A Brownhill, P Wong, P Locke, JD Zajac, AS Cheung

2021-07-13

Context: The safety and efficacy of feminizing hormone therapy in aging transgender (trans) individuals is unclear. Current recomm..

University of Melbourne Researchers